Tony Taldone

Affiliations

Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065.

Publications (13)

A Chemical Biology Approach to the Chaperome in Cancer-HSP90 and Beyond.

Cold Spring Harbor perspectives in biology

Avec: Tony Taldone , Tai Wang , Anna Rodina , Naga Vara Kishore Pillarsetty , Chander S Digwal , Sahil Sharma , Pengrong Yan , Suhasini Joshi , Piyusha P Pagare , Alexander Bolaender , Gail J Roboz , Monica L Guzman , Gabriela Chiosis

NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90.

The Journal of biological chemistry

Avec: John D Huck , Nanette L S Que , Robert M Immormino , Liza Shrestha , Tony Taldone , Gabriela Chiosis , Daniel T Gewirth

Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system.

Nature communications

Avec: Alexander Bolaender , Danuta Zatorska , Huazhong He , Suhasini Joshi , Sahil Sharma , Chander S Digwal , Hardik J Patel , Weilin Sun , Brandon S Imber , Stefan O Ochiana , Maulik R Patel , Liza Shrestha , Smit K Shah , Shuo Wang , Rashad Karimov , Hui Tao , Pallav D Patel , Ananda Rodilla Martin , Pengrong Yan , Palak Panchal , Justina Almodovar , Adriana Corben , Andreas Rimner , Stephen D Ginsberg , Serge Lyashchenko , Eva Burnazi , Anson Ku , Teja Kalidindi , Sang Gyu Lee , Milan Grkovski , Bradley J Beattie , Pat Zanzonico , Jason S Lewis , Steve Larson , Anna Rodina , Nagavarakishore Pillarsetty , Viviane Tabar , Mark P Dunphy , Tony Taldone , Fumiko Shimizu , Gabriela Chiosis

Paradigms for Precision Medicine in Epichaperome Cancer Therapy.

Cancer cell

Avec: Nagavarakishore Pillarsetty , Komal Jhaveri , Tony Taldone , Eloisi Caldas-Lopes , Blesida Punzalan , Suhasini Joshi , Alexander Bolaender , Mohammad M Uddin , Anna Rodina , Pengrong Yan , Anson Ku , Thomas Ku , Smit K Shah , Serge Lyashchenko , Eva Burnazi , Tai Wang , Nicolas Lecomte , Yelena Janjigian , Anas Younes , Connie W Batlevi , Monica L Guzman , Gail J Roboz , Jacek Koziorowski , Pat Zanzonico , Mary L Alpaugh , Adriana Corben , Shanu Modi , Larry Norton , Steven M Larson , Jason S Lewis , Gabriela Chiosis , John F Gerecitano , Mark P S Dunphy

The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.

Nature communications

Avec: Maria Carmen Inda , Suhasini Joshi , Tai Wang , Alexander Bolaender , Srinivasa Gandu , John Koren Iii , Alicia Yue Che , Tony Taldone , Pengrong Yan , Weilin Sun , Mohammad Uddin , Palak Panchal , Matthew Riolo , Smit Shah , Afsar Barlas , Ke Xu , Lon Yin L Chan , Alexandra Gruzinova , Sarah Kishinevsky , Lorenz Studer , Valentina Fossati , Scott A Noggle , Julie R White , Elisa de Stanchina , Sonia Sequeira , Kyle H Anthoney , John W Steele , Katia Manova-Todorova , Sujata Patil , Mark P Dunphy , NagaVaraKishore Pillarsetty , Ana C Pereira , Hediye Erdjument-Bromage , Thomas A Neubert , Anna Rodina , Stephen D Ginsberg , Natalia De Marco Garcia , Wenjie Luo , Gabriela Chiosis

Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone.

Cell reports

Avec: Pengrong Yan , Hardik J Patel , Sahil Sharma , Adriana Corben , Tai Wang , Palak Panchal , Chenghua Yang , Weilin Sun , Thais L Araujo , Anna Rodina , Suhasini Joshi , Kenneth Robzyk , Srinivasa Gandu , Julie R White , Elisa de Stanchina , Shanu Modi , Yelena Y Janjigian , Elizabeth G Hill , Bei Liu , Hediye Erdjument-Bromage , Thomas A Neubert , Nanette L S Que , Zihai Li , Daniel T Gewirth , Tony Taldone , Gabriela Chiosis

Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer.

Communications biology

Avec: Suhasini Joshi , Erica DaGama Gomes , Tai Wang , Adriana Corben , Tony Taldone , Srinivasa Gandu , Chao Xu , Sahil Sharma , Salma Buddaseth , Pengrong Yan , Lon Yin L Chan , Askan Gokce , Vinagolu K Rajasekhar , Lisa Shrestha , Palak Panchal , Justina Almodovar , Chander S Digwal , Anna Rodina , Swathi Merugu , NagaVaraKishore Pillarsetty , Vlad Miclea , Radu I Peter , Wanyan Wang , Stephen D Ginsberg , Laura Tang , Marissa Mattar , Elisa de Stanchina , Kenneth H Yu , Maeve Lowery , Olivera Grbovic-Huezo , Eileen M O'Reilly , Yelena Janjigian , John H Healey , William R Jarnagin , Peter J Allen , Chris Sander , Hediye Erdjument-Bromage , Thomas A Neubert , Steven D Leach , Gabriela Chiosis

Measuring Tumor Epichaperome Expression Using [

JCO precision oncology

Avec: Komal L Jhaveri , Carlos H Dos Anjos , Tony Taldone , Rui Wang , Elizabeth Comen , Monica Fornier , Jacqueline F Bromberg , Weining Ma , Sujata Patil , Anna Rodina , Nagavarakishore Pillarsetty , Susan Duggan , Sarhe Khoshi , Nathan Kadija , Gabriela Chiosis , Mark P Dunphy , Shanu Modi

Chemical probes and methods for single-cell detection and quantification of epichaperomes in hematologic malignancies.

Methods in enzymology

Avec: Swathi Merugu , Sahil Sharma , Justin Kaner , Chander Digwal , Mayumi Sugita , Suhasini Joshi , Tony Taldone , Monica L Guzman , Gabriela Chiosis

First-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Mark P S Dunphy , Christina Pressl , Nagavarakishore Pillarsetty , Milan Grkovski , Shanu Modi , Komal Jhaveri , Larry Norton , Bradley J Beattie , Pat B Zanzonico , Danuta Zatorska , Tony Taldone , Stefan O Ochiana , Mohammad M Uddin , Eva M Burnazi , Serge K Lyashchenko , Clifford A Hudis , Jacqueline Bromberg , Heiko M Schöder , Josef J Fox , Hanwen Zhang , Gabriela Chiosis , Jason S Lewis , Steven M Larson

Structures of Hsp90α and Hsp90β bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity.

Proteins

Avec: John D Huck , Nanette L S Que , Sahil Sharma , Tony Taldone , Gabriela Chiosis , Daniel T Gewirth

Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas.

Cancer research

Avec: M Nieves Calvo-Vidal , Nahuel Zamponi , Jan Krumsiek , Max A Stockslager , Maria V Revuelta , Jude M Phillip , Rossella Marullo , Ekaterina Tikhonova , Nikita Kotlov , Jayeshkumar Patel , Shao Ning Yang , Lucy Yang , Tony Taldone , Catherine Thieblemont , John P Leonard , Peter Martin , Giorgio Inghirami , Gabriela Chiosis , Scott R Manalis , Leandro Cerchietti

Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation.

Nature communications

Avec: Anna Rodina , Chao Xu , Chander S Digwal , Suhasini Joshi , Yogita Patel , Anand R Santhaseela , Sadik Bay , Swathi Merugu , Aftab Alam , Pengrong Yan , Chenghua Yang , Tanaya Roychowdhury , Palak Panchal , Liza Shrestha , Yanlong Kang , Sahil Sharma , Justina Almodovar , Adriana Corben , Mary L Alpaugh , Shanu Modi , Monica L Guzman , Teng Fei , Tony Taldone , Stephen D Ginsberg , Hediye Erdjument-Bromage , Thomas A Neubert , Katia Manova-Todorova , Meng-Fu Bryan Tsou , Jason C Young , Tai Wang , Gabriela Chiosis

Réseau de co-auteurs

Gabriela Chiosis 13 collaborations

Anna Rodina 8 collaborations

Suhasini Joshi 8 collaborations

Sahil Sharma 7 collaborations

Pengrong Yan 7 collaborations

Tai Wang 6 collaborations

Palak Panchal 5 collaborations

Adriana Corben 5 collaborations

Shanu Modi 5 collaborations

Chander S Digwal 4 collaborations

Alexander Bolaender 4 collaborations

Monica L Guzman 4 collaborations

Stephen D Ginsberg 4 collaborations

Nagavarakishore Pillarsetty 4 collaborations

Hediye Erdjument-Bromage 4 collaborations

Thomas A Neubert 4 collaborations

Nanette L S Que 3 collaborations

Liza Shrestha 3 collaborations

Daniel T Gewirth 3 collaborations

Weilin Sun 3 collaborations

Justina Almodovar 3 collaborations

Jason S Lewis 3 collaborations

Mark P Dunphy 3 collaborations

Srinivasa Gandu 3 collaborations

Elisa de Stanchina 3 collaborations

Swathi Merugu 3 collaborations

Gail J Roboz 2 collaborations

John D Huck 2 collaborations

Danuta Zatorska 2 collaborations

Hardik J Patel 2 collaborations

Stefan O Ochiana 2 collaborations

Smit K Shah 2 collaborations

Serge Lyashchenko 2 collaborations

Eva Burnazi 2 collaborations

Anson Ku 2 collaborations

Milan Grkovski 2 collaborations

Bradley J Beattie 2 collaborations

Pat Zanzonico 2 collaborations

Komal Jhaveri 2 collaborations

Mohammad M Uddin 2 collaborations

Yelena Janjigian 2 collaborations

Mary L Alpaugh 2 collaborations

Larry Norton 2 collaborations

Steven M Larson 2 collaborations

Mark P S Dunphy 2 collaborations

Lon Yin L Chan 2 collaborations

Julie R White 2 collaborations

Katia Manova-Todorova 2 collaborations

Sujata Patil 2 collaborations

NagaVaraKishore Pillarsetty 2 collaborations

Chenghua Yang 2 collaborations

Chao Xu 2 collaborations

Naga Vara Kishore Pillarsetty 1 collaboration

Piyusha P Pagare 1 collaboration

Robert M Immormino 1 collaboration

Huazhong He 1 collaboration

Brandon S Imber 1 collaboration

Maulik R Patel 1 collaboration

Shuo Wang 1 collaboration

Rashad Karimov 1 collaboration

Hui Tao 1 collaboration

Pallav D Patel 1 collaboration

Ananda Rodilla Martin 1 collaboration

Andreas Rimner 1 collaboration

Teja Kalidindi 1 collaboration

Sang Gyu Lee 1 collaboration

Steve Larson 1 collaboration

Viviane Tabar 1 collaboration

Fumiko Shimizu 1 collaboration

Eloisi Caldas-Lopes 1 collaboration

Blesida Punzalan 1 collaboration

Thomas Ku 1 collaboration

Nicolas Lecomte 1 collaboration

Anas Younes 1 collaboration

Connie W Batlevi 1 collaboration

Jacek Koziorowski 1 collaboration

John F Gerecitano 1 collaboration

Maria Carmen Inda 1 collaboration

John Koren Iii 1 collaboration

Alicia Yue Che 1 collaboration

Mohammad Uddin 1 collaboration

Matthew Riolo 1 collaboration

Smit Shah 1 collaboration

Afsar Barlas 1 collaboration

Ke Xu 1 collaboration

Alexandra Gruzinova 1 collaboration

Sarah Kishinevsky 1 collaboration

Lorenz Studer 1 collaboration

Valentina Fossati 1 collaboration

Scott A Noggle 1 collaboration

Sonia Sequeira 1 collaboration

Kyle H Anthoney 1 collaboration

John W Steele 1 collaboration

Ana C Pereira 1 collaboration

Natalia De Marco Garcia 1 collaboration

Wenjie Luo 1 collaboration

Thais L Araujo 1 collaboration

Kenneth Robzyk 1 collaboration

Yelena Y Janjigian 1 collaboration

Elizabeth G Hill 1 collaboration

Bei Liu 1 collaboration

Zihai Li 1 collaboration

Erica DaGama Gomes 1 collaboration

Salma Buddaseth 1 collaboration

Askan Gokce 1 collaboration

Vinagolu K Rajasekhar 1 collaboration

Lisa Shrestha 1 collaboration

Vlad Miclea 1 collaboration

Radu I Peter 1 collaboration

Wanyan Wang 1 collaboration

Laura Tang 1 collaboration

Marissa Mattar 1 collaboration

Kenneth H Yu 1 collaboration

Maeve Lowery 1 collaboration

Olivera Grbovic-Huezo 1 collaboration

Eileen M O'Reilly 1 collaboration

John H Healey 1 collaboration

William R Jarnagin 1 collaboration

Peter J Allen 1 collaboration

Chris Sander 1 collaboration

Steven D Leach 1 collaboration

Komal L Jhaveri 1 collaboration

Carlos H Dos Anjos 1 collaboration

Rui Wang 1 collaboration

Elizabeth Comen 1 collaboration

Monica Fornier 1 collaboration

Jacqueline F Bromberg 1 collaboration

Weining Ma 1 collaboration

Susan Duggan 1 collaboration

Sarhe Khoshi 1 collaboration

Nathan Kadija 1 collaboration

Justin Kaner 1 collaboration

Chander Digwal 1 collaboration

Mayumi Sugita 1 collaboration

Christina Pressl 1 collaboration

Pat B Zanzonico 1 collaboration

Eva M Burnazi 1 collaboration

Serge K Lyashchenko 1 collaboration

Clifford A Hudis 1 collaboration

Jacqueline Bromberg 1 collaboration

Heiko M Schöder 1 collaboration

Josef J Fox 1 collaboration

Hanwen Zhang 1 collaboration

M Nieves Calvo-Vidal 1 collaboration

Nahuel Zamponi 1 collaboration

Jan Krumsiek 1 collaboration

Max A Stockslager 1 collaboration

Maria V Revuelta 1 collaboration

Jude M Phillip 1 collaboration

Rossella Marullo 1 collaboration

Ekaterina Tikhonova 1 collaboration

Nikita Kotlov 1 collaboration

Jayeshkumar Patel 1 collaboration

Shao Ning Yang 1 collaboration

Lucy Yang 1 collaboration

Catherine Thieblemont 1 collaboration

John P Leonard 1 collaboration

Peter Martin 1 collaboration

Giorgio Inghirami 1 collaboration

Scott R Manalis 1 collaboration

Leandro Cerchietti 1 collaboration

Yogita Patel 1 collaboration

Anand R Santhaseela 1 collaboration

Sadik Bay 1 collaboration

Aftab Alam 1 collaboration

Tanaya Roychowdhury 1 collaboration

Yanlong Kang 1 collaboration

Teng Fei 1 collaboration

Meng-Fu Bryan Tsou 1 collaboration

Jason C Young 1 collaboration